The Tech Inc. Tangential Flow Filtration (TFF) and Diafiltration System concentrates and buffer-exchanges proteins, vaccines, viral vectors and other biologics by tangential flow filtration. A low-shear pump circulates the feed across flat-sheet cassettes or hollow-fibre modules, and the system controls transmembrane pressure and adds diafiltration buffer automatically.

Main components

Sanitary stainless or single-use feed vessel with level control
Low-shear peristaltic or lobe pump
Holder for flat-sheet cassettes, or hollow-fibre module mount
Feed, retentate and permeate pressure, and permeate flow
Automatic diafiltration buffer addition
PLC with recipe control and batch reports

Applications: Biopharmaceutical process development, protein and enzyme concentration, vaccine and viral vector purification, and food protein work.

Send your membrane type, test conditions and sample size to mail@techincresearch.com or call +1 (289) 622-1032 for a configuration, datasheet and quotation.

Tangential Flow Filtration (TFF) and Diafiltration System

Lab system – 0.1 to 0.5 m² membrane area.

Process-development system – up to 2.5 m².

Pilot system – larger cassette holders on a mobile frame.
Membrane area: 0.1 to 2.5 m², larger on request

Pressure: up to 4 bar TMP

Wetted parts: SS316L, Ra 0.5 µm, or single-use flow path

Control: constant TMP or constant flux, automatic diafiltration
Gentle – low-shear pump protects sensitive products.

Automatic diafiltration – buffer exchange to a set volume.

Scalable – same cassette format from lab to pilot.

Documented – batch reports for process development.
Established manufacturer – part of the Davey Group since 1990, exporting to more than 110 countries.

Everything under one roof – in-house mechanical fabrication, electrical works, PLC and SCADA automation, and R&D.

Complete scope – design, supply, installation, commissioning, factory acceptance testing (FAT) and site acceptance testing (SAT).

Trusted by Saudi Aramco – an established supplier to Saudi Aramco.

Certified management systems – ISO 9001, ISO 14001 and ISO 45001, with CE marking.

Close to your project – offices in Chennai (India), Toronto (Canada), Tallinn (Estonia) and Al Khobar (Saudi Arabia).

For this product – we build UF test systems and pilot plants, and adapt them to sanitary bioprocess standards.
Engineering to your P&ID, data sheets and company standards; drawings submitted for approval before manufacture; factory acceptance testing (FAT) with client or third-party inspection; export packing and full documentation dossier; installation, commissioning and site acceptance testing (SAT); operator training, spares and after-sales support worldwide. Contact mail@techincresearch.com or +1 (289) 622-1032.
Tangential Flow Filtration: Getting Concentration and Diafiltration Right
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Filter and Membrane Integrity Tester – integrity testing of filters and cassettes.

Large Crossflow Membrane Test Cell (140 cm²) – large crossflow test cells.